CBD and epilepsy
About one third of children suffering from different forms of epilepsy experienced a more than 50 % reduction in seizures by the use of oral cannabis extracts, researchers at the Medical Campus of the University of Colorado in Denver reported in the journal Epilepsy & Behavior. They conducted a retrospective chart review of children and adolescents who were given cannabis extracts. Seventy-five patients were identified of which 57% reported any improvement in seizure control and 33% reported a more than 50% reduction in seizures (responders).
The responder rate varied based on epilepsy syndrome: Dravet 23%, Doose (Myoclonic astatic epilepsy) 0%, and Lennox-Gastaut syndrome 88.9%. Additional benefits reported included: improved behavior/alertness (33%), improved language (10%), and improved motor skills (10%). Adverse events occurred in 44% of patients including increased seizures (13%) and somnolence/fatigue (12%). Rare adverse events included developmental regression, abnormal movements, status epilepticus requiring intubation, and death.