cropped-Ultimo-logo-Copia.jpgA large body of evidence shows that cannabinoids, in addition to their well-known palliative effects on some cancer-associated symptoms, can reduce tumor growth in animal models of cancer. They do so by modulating key cell signaling pathways involved in the control of cancer cell proliferation and survival. in addition, cannabinoids inhibit angiogenesis and cell proliferation in different types of tumors in laboratory animals. By contrast, little is known about the biological role of the endocannabinoid system in cancer physic-pathology, and several studies suggest that it may be over-activated in cancer. 



Cannabidiol as potential anticancer drug 

Cannabidiol inhibits angiogenesis by multiple mechanisms 

The inhibitory effects of cannabidiol on systemic malignant tumors 

Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1 


Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1C 

COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells

Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells 

Media ignored expert’s shocking findings that marijuana helps prevent lung cancer


Towards the use of non-psychoactive cannabinoids for prostate cancer 

In Vitro Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines

Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent 

Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer 

Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidio


Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma 

Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy 

Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis 

Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells

Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration 


Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival 

Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines 

Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas 

Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism 

Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target 

Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents 

Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect 

Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme 

“The combination of cannabidiol and Δ9-tetrahydrocannabinol enhances the anticancer effects of radiation in an orthotopic murine glioma model”

“Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells”

“Cannabinoids and gliomas.”

“A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme”

“Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism”

“Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines”

“Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas”

“Inhibition of glioma growth in vivo by selective activation of the CB2 cannabinoid receptor”


Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression 

Cannabidiol-Induced Apoptosis in Human Leukemia Cells 


Anticancer activity of anandamide in human cutaneous melanoma cells 


Cannabidiol inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpes virus-infected endothelium 


Endocannabinoids in endocrine and related tumours 

A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells 


TRPV2 activation induces apoptotic cell death in human T24 bladder cancer cells: a potential therapeutic target for bladder cancer 


Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain 

Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial

Marijuana extract helps prevent chemo pain 

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