CBD User’s Manual

CBD User’s Manual 

This CBD User’s Manual for health professionals and patients addresses key questions about cannabidiol.

What Is CBD?

Cannabidiol or CBD is a non-intoxicating component of the cannabis plant with enormous therapeutic potential. Although CBD doesn’t make people feel high like THC does, it’s causing quite a buzz among scientists, health professionals, and medical marijuana patients who are using CBD-rich products to treat a wide range of conditions: chronic pain, cancer, Crohn’s, diabetes, rheumatoid arthritis, PTSD, cardiovascular disease, anxiety, antibiotic-resistant infections, multiple sclerosis, schizophrenia, and so many more. Academic research centers in the United States and elsewhere are currently studying the effects of CBD on these and other ailments. Scientists refer to CBD as a “promiscuous” compound because it confers therapeutic benefits in many different ways while tapping into how we function physiologically and biologically on a deep level.

Extensive preclinical research and some clinical studies have shown that CBD has strong anti-oxidant, anti-inflammatory, anticonvulsant, anti-depressant, anti-psychotic, anti-tumoral, and neuroprotective qualities. Cannabidiol can change the gene expression and remove beta amyloid plaque, the hallmark of Alzheimer’s, from brain cells.

Which Is Better CBD Or THC?

Cannabidiol and THC (The High Causer) are the power couple of cannabis therapeutics; they work best together. CBD and THC interact synergistically to potentiate each other’s curative qualities. CBD enhances THC’s painkilling and anticancer properties, while lessening THC’s psychoactivity. CBD can also mitigate adverse effects caused by too much THC, such as anxiety and rapid heartbeat. CBD will lower the ceiling on the THC high while prolonging its duration. (“Relaxing but not intoxicating” is how one patient described CBD-rich cannabis.) CBD broadens the range of conditions treatable with cannabis, such as liver, cardiovascular and metabolic disorders, which may be less responsive to THC-dominant remedies. CBD and THC both stimulate neurogenesis, the creation of new brain cells, in adult mammals.

What’s The Best Way To Take CBD?

The most appropriate delivery system for CBD is one that provides an optimal dose for a desired duration with few unwanted side effects.  The time of onset and duration of effect vary depending on the method of administration. CBD-rich cannabis oil products can be taken sublingually, orally (as edibles, lozenges, beverages, tinctures, and gel caps), or applied topically. Concentrated cannabis oil extracts can also be heated and inhaled with a vape pen. Inhalation is good for treating acute symptoms that require immediate attention; the effects can be felt within a minute or two and typically last for a couple of hours. The effects of orally administered CBD-rich cannabis oil can last for four hours or more, but the onset of effects is much slower (30-90 minutes) than inhalation.

Can CBD Cure Epilepsy?

Marijuana has a rich history as a medicine for quelling seizures and convulsions going back thousands of years. In the mid-19th century, the U.S. Pharmacopeia listed cannabis tincture as a treatment for pediatric epilepsy, and subsequent scientific studies have documented the anticonvulsant effects of CBD, THC, and whole plant cannabis. CBD-dominant/low- THC cannabis strains and oil extracts can facilitate dramatic improvement in some children with intractable seizure disorders. Between 10-15 percent of severe childhood epileptics who are given CBD oil products experience a near complete cessation of seizures; most improve (with a decrease but not total elimination of seizures); and some children have worse seizures when they take CBD.  

What Is The Right CBD/THC Ratio For Me?

Cannabis therapeutics is personalized medicine. There is no single ratio or strain or product that’s right for everyone. Optimize your therapeutic use of cannabis by finding the proper combination of CBD and THC that works best for you. A person’s sensitivity to THC is a key factor in determining the appropriate ratio and dosage of CBD-rich medicine. CBD can lessen or neutralize the intoxicating effects of THC. So a greater ratio of CBD-to- THC means less of a high. For those who don’t like THC, Actidiol CBD (THC free) is the perfect solution. In essence, the goal is to administer consistent, measurable doses of a CBD-rich remedy that includes as much THC as a person is comfortable with.

What Is The Optimal Dosage Of CBD? “Dosage is everything”—Paracelsus

Cannabis is used for therapeutic purposes for thousands of years and there are no reports of serious adverse effects on patients.

– High Dosage Does Not Mean Better Results

With any active ingredient and in particular with cannabinoids in high doses it does not necessarily match a more powerful effect. Scientific references refer to benefits with low dosages able to maintain constant levels of the cannabinoid in the blood during the day. 

– Everyone Is Different

What you will find on this page is meant to be a guideline, a starting point of reference. The fact remains that everyone is in a different place and will react differently to their CBD dosage. 

  • Begin with a low dose.
  • Take a few small doses over the course of the day rather than one big dose.
  • Use the same dose for several days. Observe the effects and if necessary adjust the amount until symptom relief. And to decrease amount of CBD with any worsening of symptoms.
  • Be aware of possible side effects, even though Cannabis is a very safe molecule.
  • Consult your health counselor.
  • When CBD exceeds 150mg daily, it is considered a high dosage, even if there is no established lethal CBD dose
Serving Standards is 25mg of CBD taken twice a day

– Concentrations vary between preparations:

To take CBD oil, first hold it under your tongue for it to be absorbed prior swallowing. Although extremely rare, it is possible that in some individuals an allergic reaction occurs due to the nature of the natural product. In this case discontinue the usage and contact an allergist and the producer. Constant dosing ensures greater bioavailability.

Preparation dosage

Begin with a serving Standard of 25mg of CBD taken twice a day, can vary on diseases.

Concentrations vary between preparations:

– CBD dosages for different treatments: 

Mayo Clinic suggests CBD dosages based on scientific research, publications, traditional use, or expert opinion. Cannabinoid dosages and duration of treatment depend largely on the disease.

  • To increase appetite in cancer patients: 2.5 milligrams of THC by mouth with or without 1 mg of CBD for six weeks
  • To treat chronic pain: 2.5-20 mg CBD by mouth for an average of 25 days
  • To treat epilepsy: 200-300 mg of CBD by mouth daily for up to 4.5 months
  • To treat movement problems associated with Huntington’s disease: 10 mg per kilogram of CBD by mouth daily for six weeks
  • To treat sleep disorders: 40-160 mg CBD by mouth.
  • To treat atopic dermatitis (itchy, scaly skin rashes), hemp seed oil has been taken by mouth for 20 weeks.
  • To treat multiple sclerosis symptoms: Cannabis plant extracts containing 2.5-120 milligrams of a THC-CBD combination by mouth daily for 2-15 weeks. A mouth spray might contain 2.7 milligrams of THC and 2.5 milligrams of CBD at doses of 2.5-120 milligram for up to eight weeks..
  • To treat schizophrenia: 40-1,280 mg CBD by mouth daily for up to four weeks
  • To treat glaucoma: a single CBD dose of 20-40 mg under the tongue. Doses greater than 40 mg may actually increase eye pressure.

Cannabis compounds have biphasic properties, which means that low and high doses of the same substance can produce opposite effects. Small doses of cannabis tend to stimulate; large doses sedate. CBD has no known adverse side effects, but an excessive amount of CBD could be less effective therapeutically than a moderate dose. “Less is more” is often the case with respect to cannabis therapy.

What Should One Look For When Choosing A CBD-Rich Product?

Look for products with clear labels showing the quantity and ratio of CBD and THC per dose, a manufacturing date, and a batch number (for quality control). Select products with quality ingredients: No corn syrup, transfats, GMOs, artificial additives, thinning agents or preservatives. CBD-rich products should be lab tested for consistency and verified as being free of mold, bacteria, pesticides, solvent residues, and other contaminants. 

Is It Safe To Inhale Hemp CBD Oil Fumes From A Vape Pen?

Many cannabis- and hemp-derived CBD vape oil products include a thinning agent, which dilutes the oil that is heated and inhaled by vape pen users. Beware of vape pen oil that contains propylene glycol. When overheated, this chemical additive produces formaldehyde, a carcinogen, as a byproduct, according to a 2015 report in the New England Journal of Medicine. Why do so many vape oil products contain this thinning agent? It’s because of the dubious quality of the extracted material from which these unregulated cannabis oil products are made.

Does CBD Have Any Adverse Side Effects? What About Drug Interactions?

CBD is a very safe substance, but patients taking other medications should check with their doctor about drug interactions, which are more likely when consuming high doses of single-molecule CBD products. At sufficient dosages, CBD will temporarily deactivate cytochrome P450 enzymes, thereby altering how we metabolize a wide range of compounds, including THC. Cytochrome P450 enzymes metabolize more than 60 percent of Big Pharma meds. CBD is a more potent inhibitor of cytochrome P450 than the grapefruit compound Bergapten, so ask your doctor if grapefruit interacts with your medication. If grapefruit does, then CBD probably does, too.