Cannabidiol and bone fracture

Cannabidiol improves bone fracture healing in rats

Scientists of the Bone Laboratory of Hebrew University of Jerusalem, Israel, reported that the major non-psychoactive cannabis constituent, cannabidiol (CBD), enhances the biomechanical properties of healing bone fractures in rats. The maximal load capacity, but not the stiffness, of thigh bones from rats given a mixture of CBD and THC for 8 weeks was markedly increased by CBD. This effect does not apply to THC, and a combination with THC was not advantageous over CBD alone.

The callus material density was unaffected by CBD and/or THC. Fracture callus is a mass of heterogeneous tissue, which is later transformed to bone. CBD stimulated enzymes responsible for the cross-linking of collagen, the main structural protein of connective tissues. Authors wrote that this “is likely to contribute to the improved biomechanical properties of the fracture callus. Taken together, these data show that CBD leads to improvement in fracture healing and demonstrate the critical mechanical role of collagen crosslinking enzymes.”

Kogan NM, Melamed E, Wasserman E, Raphael B, Breuer A, Stok KS, Sondergaard R, Escudero AV, Baraghithy S, Attar-Namdar M, Friedlander-Barenboim S, Mathavan N, Isaksson H, Mechoulam R, Müller R, Bajayo A, Gabet Y, Bab I. Cannabidiol, a Major Non-Psychotrophic Cannabis Constituent Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts. J Bone Miner Res. 2015 Mar 19. [in press]

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